Preimplantation Genetic Testing for IVF: PGT-A and PGT-M
Maximizing Your Chances of Success with Chromosome Abnormality Screening
Preimplantation genetic testing (PGT) is a vital step in the in vitro fertilization (IVF) process that involves examining the genetic makeup of embryos to identify any potential chromosomal abnormalities. There are two main types of PGT: Preimplantation Genetic Testing for Aneuploidy (PGT-A) and Preimplantation Genetic Testing for Monogenetic Disease (PGT-M).
PGT-A is used to assess genetically unbalanced embryos and can be particularly helpful for women in their late thirties and early forties, who are at an increased risk of having eggs with chromosome aneuploidies. These abnormalities can lead to a higher incidence of genetically unbalanced embryos during IVF treatment, but PGT-A can help identify these embryos and improve the chances of a successful pregnancy.
PGT-M, on the other hand, is used to test for specific genetic conditions such as Sickle Cell Anemia, Cystic Fibrosis, or Beta Thalassemia. This type of testing can be offered to couples who have a genetic condition or who are carriers of genetic conditions during IVF treatment. Approximately 1 in 100 babies is born with a genetic condition that can have a significant impact on the family. PGT-M can help identify embryos that may be affected by these conditions and allow couples to make informed decisions about their treatment.
When considering PGT as part of your IVF treatment, it's important to carefully weigh the benefits and risks with your doctor and a genetic counselor. With the right information and support, you can make the best decision for your individual situation and maximize your chances of success.
Summary of the Genetic Testing:
Genetic testing during in vitro fertilization (IVF) treatment can be a useful tool for identifying potential issues before the embryo transfer. There are two main types of genetic testing: Preimplantation Genetic Testing for Aneuploidy (PGT-A) and Preimplantation Genetic Testing for Monogenetic Disease (PGT-M). PGT-A is used to detect genetically unbalanced embryos, which are more common in women in their late 30s and early 40s. PGT-M is used to detect specific genetic conditions, such as Sickle Cell Anaemia, Cystic Fibrosis, or Beta Thalassemia, in couples who are carriers of these conditions or who have a family history of them. By identifying these issues early on, genetic testing can help increase the chances of a successful pregnancy and a healthy baby.
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